Cancer of Major Salivary Glands, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 1,130 cases and 571,603 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Cancer of Major Salivary Glands — filed in the GWAS Catalog as "Cancer of major salivary glands (PheCode 145.3)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 5 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 1,130 cases and 571,603 controls (African American or Afro-Caribbean ancestry, European ancestry). It contributes 5 positions: rs190445492 (TET2-AS1), rs188788102 (near LINC01070), rs529003548 (PPFIA2-AS2), rs587678021 (near SLC2A6), rs575627503 (PALS2). PMID:39024449.
The catalogue maps the 5 positions to 5 genes: TET2-AS1, LINC01070, PPFIA2-AS2, SLC2A6, PALS2. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs190445492 in TET2-AS1 carries the strongest signal: P = 10-12, in Verma A et al. 2024.
Association records say which positions differ, on average, between people with Cancer of Major Salivary Glands and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Cancer of Major Salivary Glands is diagnosed by a clinician — not from a genotype. None of the 5 variants on this page is used by any guideline to predict, screen for or diagnose it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Cancer of Major Salivary Glands comes down to these specific, well-studied positions — not a diagnosis.
TET2-AS1 · rs190445492
See detailed info →near LINC01070 · rs188788102
See detailed info →PPFIA2-AS2 · rs529003548
See detailed info →near SLC2A6 · rs587678021
See detailed info →Databases, guidelines and references
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Cancer of Major Salivary Glands. MyGeneLog™. https://www.mygenelog.com/conditions/cancer-of-major-salivary-glands
In the GWAS Catalog, Cancer of Major Salivary Glands is filed as "Cancer of major salivary glands (PheCode 145.3)". Rather than define it, this page lists the genome-wide findings: 5 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 1,130 cases and 571,603 controls (African American or Afro-Caribbean ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 5 genes: TET2-AS1, LINC01070, PPFIA2-AS2, SLC2A6, PALS2. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Cancer of Major Salivary Glands is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.