Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
8 results in Infectious
COVID-19 with Respiratory Failure Requiring Mechanical Ventilation, as genome-wide studies have reported it: 3 positions from 1 study, the largest recording 13,052 cases and 1,438,150 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Read more → InfectiousOne of the best-known examples in human genetics of a disease shaping the genome directly — and a 2013 study found even its most famous protective variant works differently in different African populations.
Read more → InfectiousTwo of this page's three findings go further than a statistical association — one traced to impaired immune-cell movement, the other confirmed by breeding mice that lack the gene and watching them get sicker.
Read more → InfectiousA reactivation, decades later, of the same virus that caused chickenpox in childhood — and the strongest genetic signal for who gets it sits, unsurprisingly, in the immune system's own HLA region.
Read more → InfectiousA digestive condition most often caused by Helicobacter pylori infection or NSAID use — a 2021 UK Biobank GWAS of 456,327 people found genome-wide significant loci and, unusually, found the disease shares genetics with depression as well as with other digestive conditions.
Read more → InfectiousAn infectious disease caused by Mycobacterium leprae, curable with multidrug therapy, whose genetics keep pointing at the same immune pathways this site already covers for Crohn's disease, ulcerative colitis and psoriasis.
Read more → InfectiousTwo ways of asking the same question — parent-reported diarrhoea at around age one, and the same thing confirmed by a doctor — and one study found both point at the same locus: FUT2, the gene that decides whether the gut lining is a welcoming place for rotavirus and norovirus.
Read more → InfectiousWhether an infection becomes chronic is decided largely by the host, and the strongest host signal is in the genes that decide what the immune system is shown.
Read more →One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.