Squamous Cell Carcinoma, as genome-wide studies have reported it: 7 positions from 3 studies, the largest recording 9,674 cases and 625,657 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Squamous Cell Carcinoma — filed in the GWAS Catalog as "Squamous cell carcinoma (MTAG)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 7 positions from 3 studies, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 19,932 cases and 600,332 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 3 positions: rs9834622 (near TP63), rs186916993 (ALK), rs369608544 (RMST). PMID:39024449.
Seviiri M et al. 2022, in Nature Communications — A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma. Sample in the catalogue's record: 7,402 cases and 286,892 controls (European ancestry). It contributes 3 positions: rs7534124 (near CTSS), rs251465 (PPARGC1B), rs1137134 (LURAP1L-AS1). PMID:36496446.
Liyanage UE et al. 2019, in Human Molecular Genetics — Combined analysis of keratinocyte cancers identifies novel genome-wide loci. Studied in 9,674 cases and 625,657 controls (European ancestry). It contributes one position: rs11707807 (LPP). PMID:31174203.
The 7 positions sit in or beside 7 genes: TP63, ALK, RMST, CTSS, PPARGC1B, LURAP1L-AS1, LPP. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
The strongest association in the records is rs7534124 near CTSS, reported by Seviiri M et al. 2022 at P = 8 × 10-36.
Read this page as a list of findings about Squamous Cell Carcinoma, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Squamous Cell Carcinoma is diagnosed by a clinician — not from a genotype. None of the 7 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Squamous Cell Carcinoma comes down to these specific, well-studied positions — not a diagnosis.
The studies behind these variants recruited participants from different ancestries — a result found in one population doesn't always transfer to another. Based on 1 of 7 linked studies with a resolved discovery ancestry.
Databases, guidelines and references
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Squamous Cell Carcinoma. MyGeneLog™. https://www.mygenelog.com/conditions/squamous-cell-carcinoma
Squamous Cell Carcinoma is the condition the GWAS Catalog files under "Squamous cell carcinoma (MTAG)". This page does not define it in its own words; it lists what genome-wide studies have reported: 7 positions from 3 studies, with each study's sample and citation.
Genes play a part: 7 positions have been linked to it, the largest study recording 9,674 cases and 625,657 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 7 genes: TP63, ALK, RMST, CTSS, PPARGC1B, LURAP1L-AS1, LPP. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Squamous Cell Carcinoma from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.