Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
10 results in Hematologic
Pernicious Anemia, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 1,429 cases and 570,568 controls (African American or Afro-Caribbean ancestry, European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Read more → HematologicFolate-deficiency Anemia, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 1,353 cases and 570,069 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → HematologicAcquired Hemolytic Anemias, as genome-wide studies have reported it: 10 positions from 1 study, the largest recording 960 cases and 571,231 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → HematologicImmunoglobulin Light Chain (AL) Amyloidosis, as genome-wide studies have reported it: 4 positions from 2 studies, the largest recording 1,229 cases, 7,526 controls. Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → HematologicA rare histiocytosis whose first-ever genome-wide study found one germline risk variant near SETBP1 — a gene otherwise known for its role in clonal blood-cell mutation.
Read more → HematologicHow many monocytes — the white blood cells that become macrophages, the immune system's general-purpose cleanup and signalling cells — circulate in a person's blood. A measurement rather than a disease, the same way this site's C-reactive protein page is: a number a blood test reports, with some of its variation explained by common genetics.
Read more → HematologicHow fast red blood cells break down in sickle cell anaemia varies between patients in ways that matter clinically. This variant reached genome-wide significance in a study whose headline finding was elsewhere (NPRL3) — its own nearest genes are olfactory receptors with no established link to blood biology, stated plainly rather than dressed up with an invented mechanism.
Read more → HematologicThe numbers on a routine blood test are strongly heritable, and one of them turned into a medicine: BCL11A was found because it moved fetal haemoglobin, and silencing it now treats sickle cell disease. The same data also warns that several of these numbers mark disease risk without causing it.
Read more → HematologicA promoter variant that silences the Duffy antigen on red cells, protecting against Plasmodium vivax malaria and causing a normal, lower neutrophil count that is routinely and wrongly treated as disease in people of African ancestry.
Read more → HematologicA common inherited change in the F5 gene that makes blood slightly slower to switch off clotting, raising the risk of deep vein thrombosis and pulmonary embolism. Most carriers never have a clot.
Read more →One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.