Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
4 results in Pharmacogenomics
A common OPRM1 variant alters the mu-opioid receptor and has been studied in relation to opioid dose requirements and naltrexone response, but CPIC found the evidence too weak and inconsistent to support any clinical dosing recommendation.
Read more → PharmacogenomicsA common CYP1A2 variant affects how quickly the body clears caffeine. A widely repeated claim that 'slow' metabolizers face higher heart-attack risk from coffee rests on limited evidence that has not held up well in larger studies.
Read more → PharmacogenomicsMuscle aches are the most common reason people stop taking statins. A common variant in SLCO1B1, the liver transporter that pulls statins out of the bloodstream, is linked to higher statin levels and higher myopathy risk.
Read more → PharmacogenomicsWarfarin is an anticoagulant whose effective dose varies enormously between people. Common variation in VKORC1 — warfarin's direct target — plus CYP2C9 and CYP4F2 explains a large share of that variability.
Read more →One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.