Cancer of Other Male Genital Organs, as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 3,018 cases and 569,607 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Cancer of Other Male Genital Organs — filed in the GWAS Catalog as "Cancer of other male genital organs (PheCode 187)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 4 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 3,018 cases and 569,607 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 4 positions on this page: rs191851063 (KLF12), rs905839831 (NWD2), rs569391174 (PCDH15), rs77361099 (LINC01723). PMID:39024449.
The catalogue maps the 4 positions to 4 genes: KLF12, NWD2, PCDH15, LINC01723. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
The strongest association in the records is rs191851063 in KLF12, reported by Verma A et al. 2024 at P = 10-15.
Read this page as a list of findings about Cancer of Other Male Genital Organs, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Cancer of Other Male Genital Organs is diagnosed by a clinician — not from a genotype. None of the 4 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Cancer of Other Male Genital Organs comes down to these specific, well-studied positions — not a diagnosis.
PCDH15 · rs569391174
See detailed info →LINC01723 · rs77361099
See detailed info →Databases, guidelines and references
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Cancer of Other Male Genital Organs. MyGeneLog™. https://www.mygenelog.com/conditions/cancer-of-other-male-genital-organs
Cancer of Other Male Genital Organs is the condition the GWAS Catalog files under "Cancer of other male genital organs (PheCode 187)". This page does not define it in its own words; it lists what genome-wide studies have reported: 4 positions from 1 study, with each study's sample and citation.
Genes play a part: 4 positions have been linked to it, the largest study recording 3,018 cases and 569,607 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 4 genes: KLF12, NWD2, PCDH15, LINC01723. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Cancer of Other Male Genital Organs is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.