Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
18 results in Neurological
Meniere's Disease, as genome-wide studies have reported it: 11 positions from 3 studies, the largest recording 8,900 cases and 1,881,340 controls (European ancestry, East Asian ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Read more → NeurologicalHippocampal Atrophy, as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 1,149 cases, 188 controls, 336 individuals (European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → NeurologicalA leading cause of stroke and cognitive decline, mapped by a 2022 study of over 41,000 people that found 11 risk loci and traced one, TRIM47, all the way to a lab experiment on brain blood vessels.
Read more → NeurologicalThe second most common form of dementia, mapped by the largest genome-wide study of it to date — which confirmed GBA1 among four known risk genes and found one new one.
Read more → NeurologicalThe most common movement disorder, highly heritable in twin studies — and, unusually for a GWAS finding on this site, one of its risk genes comes with a direct experimental link to lower activity actually lowering risk.
Read more → NeurologicalA seizure triggered by fever in a young child — and, for two of this page's five variants, one specific to seizures after the MMR vaccine, at a gene that is literally the measles virus's own entry point into human cells.
Read more → NeurologicalTwo loci from a 635,969-person veteran health atlas study, not a dedicated ME/CFS study — and a real gap worth stating plainly: the dedicated studies making news this year, DecodeME and a 46,450-case meta-analysis, are not yet in the public GWAS Catalog this site draws from, so their findings are not here yet either.
Read more → NeurologicalA rare cerebral vasculopathy that narrows the brain's major arteries and can cause stroke in children or young adults — a 2018 GWAS found 10 new risk loci, and one surprising signal tied to homocysteine metabolism rather than the disease's usual dominant gene.
Read more → NeurologicalHuntington's disease itself comes from one well-known cause, a CAG-repeat expansion in HTT — this page is about something narrower: one variant found to shift the age symptoms begin, and only in the same Venezuelan family cluster whose DNA first mapped HTT itself, in 1983.
Read more → NeurologicalCognitive decline caused by damage to the brain's blood supply, the second most common cause of dementia. A variant near a gene called SYK was not just statistically associated with it — a laboratory experiment showed the risk version actually changes how a gene's message gets edited.
Read more → NeurologicalAlzheimer genetics comes in three tiers that behave nothing alike: rare changes that nearly decide the outcome, one common variant that matters a great deal, and a long tail that each move risk a little. This catalogue holds the second and part of the third, and none of the first — and several of the famous genes are here under completely different headings.
Read more → NeurologicalOne of the most heritable conditions in psychiatry, and its first genome-wide study found nothing that met the threshold. The variant on this page is that study’s top signal — published because a near miss in a small sample is information too.
Read more → NeurologicalA rare, rapidly fatal prion disease of the brain — a 2020 GWAS, the first for this condition, found a genome-wide significant risk variant near STX6, a gene already separately implicated in another neurodegenerative disease.
Read more → NeurologicalNine in ten cases have no family history, and for a long time that ninety percent was the part genetics could say least about. It took 13,225 people to find one new position.
Read more → NeurologicalNot a bad headache. The two loci that replicated in migraine without aura point at neurons and at blood vessel walls — which is the century-old argument about what migraine is, showing up in the data.
Read more → NeurologicalSix of these positions shift the odds slightly and mean nothing on their own. The seventh is different in kind, and it is the reason this page spends more space on what a result cannot tell you than on what it can.
Read more → NeurologicalA common neurological sleep-related movement disorder causing an overwhelming urge to move the legs, worse at rest and in the evening and relieved by movement, which fragments sleep and often runs in families.
Read more → NeurologicalAPOE is the strongest common genetic influence on late-onset Alzheimer's disease. Its e4 form raises risk and e2 lowers it, but APOE genotype predicts probability rather than destiny.
Read more →One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.