Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
33 results in Autoimmune
Thyroiditis, as genome-wide studies have reported it: 8 positions from 1 study, the largest recording 2,522 cases and 628,394 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → AutoimmuneAutoimmune Neurological Syndromes with anti-GAD65 Autoantibodies, as genome-wide studies have reported it: 7 positions from 1 study, the largest recording 167 cases and 1,047 controls. Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → AutoimmuneOtosclerosis, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 3,504 cases and 861,198 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Read more → AutoimmuneCutaneous Lupus Erythematosus, as genome-wide studies have reported it: 6 positions from 2 studies, the largest recording 1,359 cases and 571,562 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → AutoimmuneA chronic inflammatory skin disease causing painful lumps, abscesses and tunnels in skin folds, often mistaken for severe acne or recurring boils -- a 2026 multiomics study found its genetics touch lipid handling, the skin barrier, and cellular waste disposal, not one single pathway.
Read more → AutoimmuneThe clinical name for what is commonly called Hashimoto's thyroiditis — the immune system attacking the thyroid, usually leading to an underactive gland. A 2026 meta-analysis of nearly 2.9 million genomes, covering five thyroid diseases at once, found hundreds of loci and real genetic overlap between this one and thyroid cancer.
Read more → AutoimmuneA fibro-inflammatory disease that can affect almost any organ, tied to a specific immune cell type and antibody. A Chinese study found 16 general susceptibility loci, mostly in immune-signalling regions; a separate Japanese study using whole-genome sequencing then found that one clinical subtype — Mikulicz's disease, which affects the salivary and lacrimal glands — has its own distinct genetics on top of the general ones.
Read more → AutoimmuneAn autoimmune disease causing fluctuating muscle weakness, and one where genetics turned out to split cleanly by age of onset: the risk locus found in early-onset cases showed no association at all in a later study restricted to people diagnosed after 50.
Read more → AutoimmuneA rare autoimmune blistering disease of skin and mucous membranes, whose strongest known genetic signal by far sits inside the immune system's own HLA region — the variant this page carries is a real but much smaller contributor from the same study.
Read more → AutoimmuneThis page's own gene, PRTN3, does not just sit near the disease statistically — it encodes the exact protein the disease's own antibodies attack, and the risk variant raises how much of that protein neutrophils make.
Read more → AutoimmuneA rare inflammatory disease of the aorta and its major branches, with its strongest genetic risk in the same immune region — HLA — that shapes risk for many other autoimmune diseases, and a genome-wide relatedness closest to inflammatory bowel disease.
Read more → AutoimmuneAn adult-onset autoimmune diabetes often mistaken at first for type 2 diabetes — the first systematic GWAS of LADA, published in 2018, found its strongest genetic risk overlaps with type 1 diabetes, while type 2-diabetes-associated genes also contribute to a lesser degree.
Read more → AutoimmuneA pediatric vasculitis and the leading cause of acquired heart disease in children in industrialized countries — a 2021 European-ancestry GWAS confirmed ITPKC as a susceptibility gene and found a separate, novel locus specific to the disease's most serious complication, coronary artery aneurysm.
Read more → AutoimmuneGraves' disease and Hashimoto's thyroiditis look like opposites clinically — one over-active, one under-active — but a 2012 study found genetic risk they share, including one locus also linked to celiac disease.
Read more → AutoimmuneAn autoimmune disease that dries out the glands that make tears and saliva — a 2013 study of over 4,000 people found the strongest genetic signal ever measured in the condition, at the HLA region, alongside two more confirmed loci.
Read more → AutoimmuneThe most common chronic rheumatic disease in children — a 2020 study combined genetic analysis across its several clinical subtypes and found 5 genome-wide significant risk loci, all represented on this page.
Read more → AutoimmuneEczema and psoriasis share much of their genetics at the same handful of positions — but the risk alleles there point in opposite directions, which is part of why the two diseases almost never occur in the same person.
Read more → AutoimmuneAn autoimmune disease that slowly destroys the small bile ducts inside the liver, overwhelmingly in women. Fifteen risk variants across five studies on three continents converge on the immune system, not the liver itself.
Read more → AutoimmunePatchy hair loss caused by the immune system attacking hair follicles directly — a different disease from male-pattern baldness despite the shared word "alopecia." About a 2% lifetime risk, usually starting before age 30, affecting men and women alike. The two variants here come from a 2015 meta-analysis that resolved the field's long-known HLA signal and found two loci beyond it.
Read more → AutoimmuneUsually diagnosed and discussed purely as an antibody condition, not a genetic one. The first genome-wide study of it, in 115 Japanese patients, found a locus near C1D conferring substantially elevated risk — part of a picture the paper connects to why live births stay limited even with standard treatment.
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One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.