Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 167 cases and 1,047 controls. Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies — filed in the GWAS Catalog as "Autoimmune neurological syndromes with anti-GAD65 autoantibodies" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 6 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Strippel C et al. 2023, in Brain — A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies. Studied in 167 cases and 1,047 controls. It contributes 6 positions: rs3130545 (near RNU6-1133P), rs378956 (OR2I1), rs3094633 (HCG18), rs314304 (ZAN), rs62231498 (near RTL6), rs7749544 (near RNU6-1133P). PMID:35348614.
The 6 positions lie in or near 5 genes: RNU6-1133P, OR2I1, HCG18, ZAN, RTL6. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
The strongest association in the records is rs3130545 near RNU6-1133P, reported by Strippel C et al. 2023 at P = 3 × 10-13, with an odds ratio of 0.23.
Association records say which positions differ, on average, between people with Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies is diagnosed by a clinician — not from a genotype. None of the 6 variants on this page is used by any guideline to predict, screen for or diagnose it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies comes down to these specific, well-studied positions — not a diagnosis.
near RNU6-1133P · rs7749544
See detailed info →near RNU6-1133P · rs3130545
See detailed info →OR2I1 · rs378956
See detailed info →HCG18 · rs3094633
See detailed info →ZAN · rs314304
See detailed info →near RTL6 · rs62231498
See detailed info →Databases, guidelines and references
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Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies. MyGeneLog™. https://www.mygenelog.com/conditions/autoimmune-neurological-syndromes-with-anti-gad65-autoantibodies
Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies is the condition the GWAS Catalog files under "Autoimmune neurological syndromes with anti-GAD65 autoantibodies". This page does not define it in its own words; it lists what genome-wide studies have reported: 6 positions from 1 study, with each study's sample and citation.
Genes play a part: 6 positions have been linked to it, the largest study recording 167 cases and 1,047 controls. But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 5 genes: RNU6-1133P, OR2I1, HCG18, ZAN, RTL6. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Autoimmune Neurological Syndromes with anti-GAD65 Autoantibodies is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.