Thyroiditis, as genome-wide studies have reported it: 8 positions from 1 study, the largest recording 2,522 cases and 628,394 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Thyroiditis — filed in the GWAS Catalog as "Thyroiditis (PheCode 245)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 8 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 2,522 cases and 628,394 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 8 positions on this page: rs902084651 (PDE10A), rs549207705 (near RNA5SP293), rs572792123 (near NXPH1), rs147250301 (SF3A3), rs541866506 (near RNU7-54P), rs549432880 (STK32A), rs542203472 (near LINC01248), rs528828146 (PPM1H). PMID:39024449.
The catalogue maps the 8 positions to 8 genes: PDE10A, RNA5SP293, NXPH1, SF3A3, RNU7-54P, STK32A, LINC01248, PPM1H. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs902084651 in PDE10A carries the strongest signal: P = 3 × 10-13, in Verma A et al. 2024.
Association records say which positions differ, on average, between people with Thyroiditis and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Thyroiditis is diagnosed by a clinician — not from a genotype. None of the 8 variants on this page is used by any guideline to predict, screen for or diagnose it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Thyroiditis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Thyroiditis. MyGeneLog™. https://www.mygenelog.com/conditions/thyroiditis
Thyroiditis is the condition the GWAS Catalog files under "Thyroiditis (PheCode 245)". This page does not define it in its own words; it lists what genome-wide studies have reported: 8 positions from 1 study, with each study's sample and citation.
Genes play a part: 8 positions have been linked to it, the largest study recording 2,522 cases and 628,394 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 8 genes: PDE10A, RNA5SP293, NXPH1, SF3A3, RNU7-54P, STK32A, LINC01248, PPM1H. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Thyroiditis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.