Cutaneous Lupus Erythematosus, as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 151 cases and 1,288 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Genome-wide studies have so far placed 2 positions on Cutaneous Lupus Erythematosus, from 1 study; the GWAS Catalog files the condition as "Cutaneous lupus erythematosus". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Kunz M et al. 2015, in Experimental Dermatology — Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus. Sample in the catalogue's record: 151 cases and 1,288 controls (European ancestry). From it, 2 positions on this page: rs9267531 (CSNK2B), rs3131060 (FLOT1). PMID:25827949.
The 2 positions lie in or near 2 genes: CSNK2B, FLOT1. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Kunz M et al. 2015 reported the smallest P value on this page — P = 3 × 10-14, with an odds ratio of 2.62 — at rs9267531 in CSNK2B.
Association records say which positions differ, on average, between people with Cutaneous Lupus Erythematosus and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Cutaneous Lupus Erythematosus is diagnosed by a clinician — not from a genotype. None of the 2 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Cutaneous Lupus Erythematosus comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Cutaneous Lupus Erythematosus. MyGeneLog™. https://www.mygenelog.com/conditions/cutaneous-lupus-erythematosus
Cutaneous Lupus Erythematosus is the condition the GWAS Catalog files under "Cutaneous lupus erythematosus". This page does not define it in its own words; it lists what genome-wide studies have reported: 2 positions from 1 study, with each study's sample and citation.
Genes play a part: 2 positions have been linked to it, the largest study recording 151 cases and 1,288 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 2 genes: CSNK2B, FLOT1. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Cutaneous Lupus Erythematosus from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.