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Caffeine and energy drinks

The most-consumed drug on earth, metabolised at wildly different speeds.

Why this topic Energy drinks are the fastest-growing thing people put in their bodies.

From our blog

Two identical cups of coffee, one calm and one trembling

Why One Cup of Coffee Wrecks You and Not Your Friend: Meet CYP1A2

One friend sleeps fine after a late americano; another shakes after a single cup. There is a real gene behind …

What this topic connects to

Caffeine and energy drinks Variant: rs762551 rs762551 Variant Variant: rs2470893 rs2470893 Variant Variant: rs4410790 rs4410790 Variant Variant: rs2074356 rs2074356 Variant Variant: rs6968865 rs6968865 Variant Variant: +22 more +22 more Variant Caffeine and energy drinks Caffeine and energy drinks

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

Variants that share a paper with this

Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.

rs762551

CYP1A2

Caffeine metabolism

42 papers →

rs2470893

ARID3B

Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)

9 papers →

rs4410790

AGR3

Urinary albumin excretion

9 papers →

rs2074356

C12orf51

Renal function-related traits (BUN)

5 papers →

rs6968865

AHR

Coffee consumption

4 papers →

rs671

ALDH2

Alcohol flush reaction

3 papers →

rs12931267

MC1R

Hair color

2 papers →

rs1495741

NAT2

Triglycerides

2 papers →

rs10401969

NCAN

LDL cholesterol

1 paper →

rs1047891

CPS1

Plasma homocysteine levels (post-methionine load test)

1 paper →

rs11066015

ACAD10

Esophageal cancer

1 paper →

rs11676272

ADCY3

Body mass index

1 paper →

rs12229654

MYL2

Alcohol consumption

1 paper →

rs141640975

CUBN

Urinary albumin excretion

1 paper →

rs1421085

FTO

Obesity

1 paper →

rs17367504

NPPA

Systolic blood pressure

1 paper →

rs1800437

GIPR

Obesity

1 paper →

rs1803274

BCHE

Cardiovascular disease risk factors

1 paper →

rs301

LPL

Metabolic syndrome (bivariate traits)

1 paper →

rs356219

SNCA

Parkinson's disease

1 paper →

rs429358

APOE

Lewy body disease

1 paper →

rs5215

KCNJ11

Type 2 diabetes

1 paper →

rs6834314

HSD17B13

Liver enzyme levels (alanine transaminase)

1 paper →

rs780094

GCKR

Uric acid levels

1 paper →

rs7800944

MLXIPL

Coffee consumption (cups per day)

1 paper →

rs9364554

SLC22A3

Prostate cancer

1 paper →

rs9389269

HBS1L

Red blood cell traits

1 paper →

How this was counted

Europe PMC, title and abstract only, searched for “caffeine consumption”, “caffeine metabolism”, “coffee consumption” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.

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Caffeine and energy drinks. MyGeneLog™. https://www.mygenelog.com/topics/caffeine

Questions about Caffeine and energy drinks

What is Caffeine and energy drinks?

Caffeine and energy drinks is this site's topic page for caffeine genetics — the most-consumed drug on earth, and one that different people metabolise at wildly different speeds.

Does genetics explain why caffeine affects some people more than others?

Partly — caffeine metabolism speed does vary by genotype, which is why the same cup keeps one person up and barely touches another. A variant here is a co-mention with that research, not a personal caffeine-sensitivity score.

Why is caffeine and energy drinks a topic on this site now?

Energy drinks are the fastest-growing thing people put in their bodies, which is what earned caffeine metabolism a page of its own this year.

How does this site decide which variants are linked to caffeine and energy drinks?

Europe PMC is searched for caffeine consumption, caffeine metabolism or coffee consumption appearing in a paper's title or abstract alongside a published rsID, recounted every month.