The most-consumed drug on earth, metabolised at wildly different speeds.
Why this topic Energy drinks are the fastest-growing thing people put in their bodies.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.
CYP1A2
Caffeine metabolism
42 papers →ARID3B
Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)
9 papers →AGR3
Urinary albumin excretion
9 papers →C12orf51
Renal function-related traits (BUN)
5 papers →AHR
Coffee consumption
4 papers →ALDH2
Alcohol flush reaction
3 papers →MC1R
Hair color
2 papers →NAT2
Triglycerides
2 papers →NCAN
LDL cholesterol
1 paper →CPS1
Plasma homocysteine levels (post-methionine load test)
1 paper →ACAD10
Esophageal cancer
1 paper →ADCY3
Body mass index
1 paper →MYL2
Alcohol consumption
1 paper →CUBN
Urinary albumin excretion
1 paper →FTO
Obesity
1 paper →NPPA
Systolic blood pressure
1 paper →GIPR
Obesity
1 paper →BCHE
Cardiovascular disease risk factors
1 paper →LPL
Metabolic syndrome (bivariate traits)
1 paper →SNCA
Parkinson's disease
1 paper →APOE
Lewy body disease
1 paper →KCNJ11
Type 2 diabetes
1 paper →HSD17B13
Liver enzyme levels (alanine transaminase)
1 paper →GCKR
Uric acid levels
1 paper →MLXIPL
Coffee consumption (cups per day)
1 paper →SLC22A3
Prostate cancer
1 paper →HBS1L
Red blood cell traits
1 paper →Europe PMC, title and abstract only, searched for “caffeine consumption”, “caffeine metabolism”, “coffee consumption” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.
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Caffeine and energy drinks. MyGeneLog™. https://www.mygenelog.com/topics/caffeine
Caffeine and energy drinks is this site's topic page for caffeine genetics — the most-consumed drug on earth, and one that different people metabolise at wildly different speeds.
Partly — caffeine metabolism speed does vary by genotype, which is why the same cup keeps one person up and barely touches another. A variant here is a co-mention with that research, not a personal caffeine-sensitivity score.
Energy drinks are the fastest-growing thing people put in their bodies, which is what earned caffeine metabolism a page of its own this year.
Europe PMC is searched for caffeine consumption, caffeine metabolism or coffee consumption appearing in a paper's title or abstract alongside a published rsID, recounted every month.