MC1R · rs12931267
Where this position leads
Conditions: Sun Sensitivity, Freckling and Skin Cancer Risk, Hair Color
What the study found
Who was studied 9,126 European ancestry individuals.
The effect Each copy of the G allele shifted the measure 0.56 higher; p = 5 × 10−87.
How common The G allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 16, band 16q24.3 — in an intron of FANCA.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2019-01-10.
ClinVar record 1267316 NM_000135.4(FANCA):c.2982-102G>C
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs12931267 is a single position in the genome, in or near the MC1R gene. Published research associates it with hair color. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk, Hair Color. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers), caffeine and energy drinks (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, PLoS Genet 2010, PMID:20585627. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hair color (rs12931267). MyGeneLog™. https://www.mygenelog.com/variants/rs12931267