Sensitive

Parkinson's disease

SNCA · rs356219

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 5,333 European ancestry cases, 12,019 European ancestry controls; replicated in 7,053 cases, 9,007 controls.

The effect Each copy of the G allele carried 1.29 times the odds of Parkinson's disease (95% confidence interval 1.25-1.33); p = 2 × 10⁻⁴⁷.

How common The G allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 4, band 4q22.1 — in an intron of LOC124900602.

What each result means

A/A No copy of the version the research linked to Parkinson's disease. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Parkinson's disease. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Stefánsson K, Martinez M

and 6 more — show all

Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW

International Parkinson Disease Genomics Consortium

Lancet (London, England) · 2011 · PMID 21292315

What people read about alongside this

Brain and memory3 Learning and focus2 Caffeine and energy drinks1 ADHD and attention1 Anxiety and worry1 Liver1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs356219

What is rs356219?

rs356219 is a single position in the genome, in or near the SNCA gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs356219 linked to?

On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs356219?

Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (3 papers), learning and focus (2 papers), caffeine and energy drinks (1 papers), adhd and attention (1 papers), anxiety and worry (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs356219 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs356219 come from?

GWAS Catalog, Lancet 2011, PMID:21292315. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Parkinson's disease (rs356219). MyGeneLog™. https://www.mygenelog.com/variants/rs356219

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