Standard

Coffee consumption (cups per day)

MLXIPL · rs7800944

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−23, with 3 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 91,462 European ancestry individuals; replicated in 30,062 European ancestry individuals, 7,964 African American individuals.

The effect Each copy of the T allele shifted the measure 0.05 lower (95% confidence interval 0.030-0.070); p = 3 × 10−11.

How common The T allele had a frequency of about 72% in the people studied.

Where it sits Chromosome 7, band 7q11.23 — in an intron of MLXIPL.

What each result means

C/C No copy of the version the research linked to Coffee consumption (cups per day). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Coffee consumption (cups per day). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Coffee consumption (cups per day). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs7800944

What is rs7800944?

rs7800944 is a single position in the genome, in or near the MLXIPL gene. Published research associates it with coffee consumption (cups per day). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs7800944?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), caffeine and energy drinks (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs7800944 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7800944 come from?

GWAS Catalog, Mol Psychiatry 2014, PMID:25288136. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Coffee consumption (cups per day) (rs7800944). MyGeneLog™. https://www.mygenelog.com/variants/rs7800944

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