Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
Birth weight is genetically linked to adult heart disease and diabetes risk — and a large study using both mother and child genotypes found that link is carried by shared genes, not by the womb environment itself.
Read more → TraitA life-course study of bone density measured across the whole body, from childhood to old age, found 80 genetic loci — and that all but two of them act the same way no matter how old you are.
Read more → TraitHow big someone’s waist measures is a genetically influenced marker of central body fat, mapped by the same large study that built this site’s hip circumference page — plus two further studies whose loci only show up once smoking or physical activity is accounted for.
Read more → TraitHow fast the heart beats at rest is substantially heritable, and one of the largest studies of it also found a genetically higher resting rate linked to a shorter life expectancy — a real, if modest, mortality signal, not a diagnosis.
Read more → TraitWhen menopause happens is highly heritable, and three studies on two continents keep landing on the same kind of gene: DNA repair. Early menopause, affecting up to 10% of women, turns out to share the same genetic architecture as ordinary variation in timing, not a separate cause.
Read more → TraitA chemokine that helps direct immune cells to sites of inflammation, mapped in a large Finnish cytokine study whose strongest hits sit right in the same signalling family the molecule itself belongs to.
Read more → TraitNot how much bone an adult has lost, but how it is built in the first place. Two studies of children's bone development found the skeleton is not one trait — different sites have different genetics — and one study found a gene that trades off muscle against bone at the exact same locus.
Read more → TraitThe proxy measure nearly all bone genetics research actually uses, from a single study of 142,487 people that went unusually far to check its statistical findings against real mouse biology — including 120 knockout mice.
Read more → TraitA common anthropometric measurement whose genetics are real and well-mapped — and whose relationship to disease risk runs the opposite way "bigger measurement, worse outcome" intuition suggests. Smaller hip circumference, not larger, tracks with more heart disease.
Read more → DevelopmentalOne of the most common congenital malformations of the male genitalia, corrected surgically in infancy. One gene, found in the field's first GWAS, has an unusually large effect for a common condition; eighteen more loci together explain a modest share of the rest.
Read more → CancerA cancer of plasma cells, the antibody-producing white blood cells. Three studies that built directly on each other tripled the number of confirmed risk loci in five years, converging on the same developmental process that makes a normal plasma cell in the first place.
Read more → InfectiousAn infectious disease caused by Mycobacterium leprae, curable with multidrug therapy, whose genetics keep pointing at the same immune pathways this site already covers for Crohn's disease, ulcerative colitis and psoriasis.
Read more → TraitWhich bacteria live in the gut, and in what proportion, is measurably shaped by host genetics — not just diet. Two independent 2016 studies, in German and Dutch cohorts, each found real genetic associations, with two results — one about vitamin D, one about lactose — that come with an obvious mechanism attached.
Read more → AutoimmuneAn autoimmune disease that slowly destroys the small bile ducts inside the liver, overwhelmingly in women. Fifteen risk variants across five studies on three continents converge on the immune system, not the liver itself.
Read more → TraitYears of schooling completed, studied genome-wide in nearly 300,000 people and then 1.1 million. A real, replicated signal exists — and even at its largest scale it explains barely a tenth of the variance in the one thing it was built to predict, in a trait shaped enormously by the society someone grows up in.
Read more → TraitA real, heritable disposition toward risk-seeking, mapped across hundreds of genome positions in over a million people. It explains a real slice of why people differ as a population, and essentially nothing about any one person's genotype.
Read more → TraitWhen baby teeth and adult teeth come in is more heritable than most people would guess — twin studies put it above 80%. Nine variants across three large studies mark some of that heritability, in genes that also shape height and facial width.
Read more → DentalThe most common chronic disease in children. One genome-wide-significant susceptibility gene has been found; the two things people actually reach for — fluoride toothpaste and xylitol gum — have a real evidence base of their own, and it is not the same size for each.
Read more → OphthalmicNearsightedness, already affecting an estimated 23% of the world and projected to reach half of it by 2050. Common-variant genetics explains only a fraction of the risk; a splicing mechanism in the X-linked cone opsin genes explains much more in some people, and the same genes are why red-green colour blindness exists.
Read more → OphthalmicThe leading cause of vision loss in older adults in high-income countries. Two genes discovered in 2005 — CFH and ARMS2 — account for most of the known genetic risk; a run of later meta-analyses added ten smaller loci, mostly in the same complement and lipid-metabolism pathways.
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One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.