Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
Warfarin is an anticoagulant whose effective dose varies enormously between people. Common variation in VKORC1 — warfarin's direct target — plus CYP2C9 and CYP4F2 explains a large share of that variability.
Read more → MetabolicTwo very common MTHFR variants modestly change how efficiently one folate-processing enzyme works. They are heavily over-claimed online; here is what the published evidence actually supports, and what it does not.
Read more → HematologicA common inherited change in the F5 gene that makes blood slightly slower to switch off clotting, raising the risk of deep vein thrombosis and pulmonary embolism. Most carriers never have a clot.
Read more → NeurologicalAPOE is the strongest common genetic influence on late-onset Alzheimer's disease. Its e4 form raises risk and e2 lowers it, but APOE genotype predicts probability rather than destiny.
Read more → MetabolicAn inherited condition in which the body absorbs more iron from food than it needs. Over decades the surplus iron can build up in the liver, heart, pancreas and joints and cause damage.
Read more →Showing 5 of 385 · page 20 of 20
One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.