Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
The largest GWAS of primary sclerosing cholangitis to date found 4 new risk loci and showed the disease is genetically distinct from the inflammatory bowel disease it so often accompanies.
Read more → TraitA two-stage GWAS found the genetic loci behind serum complement C3 and C4 levels — proteins central to the immune system's complement pathway — with an unusually clean match to this page's own variants.
Read more → ConditionA 73,265-person GWAS of rosacea symptom severity found 7 loci, split between immune-inflammatory genes and pigmentation genes — a mix that maps onto the two theories long debated about the disease.
Read more → TraitA UK Biobank study of over 125,000 people found 38 loci associated with self-reported age at first sexual intercourse, several of them shared with puberty timing, risk-taking, and temperament.
Read more → TraitFive studies, the largest covering nearly 46,000 people, found dozens of loci shaping baseline PSA level as a continuous measurement — distinct from a prostate cancer diagnosis.
Read more → TraitA pharmacogenomics study of atenolol found that heart rate response is genetically variable — but its own confirmed, replicated genes are not the ones tagged to this page's specific variants.
Read more → ConditionA 2015 study of every major myositis subtype found that one extended immune haplotype, inherited as a block, accounts for essentially all of the identified genetic risk.
Read more → ConditionThree genome-wide studies spanning a decade, ending in the Million Veteran Program, built a 24-locus genetic map of abdominal aortic aneurysm and found a causal link to diastolic blood pressure.
Read more → ConditionThree GWAS totaling tens of thousands of people, one of them tracing a link to intestinal-pathogen biology, together identified the genetic loci behind the world's most common form of glomerulonephritis.
Read more → TraitA UK Biobank study of over 220,000 people studied headache as a single, broadly self-reported experience — not restricted to a clinical migraine diagnosis — and found 28 associated loci.
Read more → TraitA study of nearly 3,000 African American participants confirmed LPA as the central gene for Lp(a) levels — and explicitly warned that a much wider stretch of nearby genes looked significant only because of local genetic ancestry, not a real biological effect.
Read more → TraitA 2018 meta-analysis of nearly 300,000 people found 124 loci shaping hair color, explaining more than a quarter of the heritability of red, blond, and black hair.
Read more → TraitAn Alzheimer's biomarker study followed people with late mild cognitive impairment and measured how quickly their cognition declined — a different, less-detailed endpoint than the same paper's headline CSF biomarker findings.
Read more → TraitA 2018 study measured 139 serum metabolites and their ratios in over 1,000 people with chronic kidney disease, finding genetic loci that illuminate how the kidney handles specific molecules.
Read more → TraitTwo GWAS of the sugar chains attached to antibody molecules found the same glycosyltransferase genes twice, plus immune-related loci already linked to autoimmune disease and blood cancers.
Read more → TraitFive separate metabolomics studies used mass spectrometry or NMR to measure hundreds of small molecules in blood and urine, and repeatedly converged on the same handful of metabolism genes.
Read more → TraitA 2017 self-reported GWAS of mosquito bite size and itchiness found 15 immune-related loci — the first genetic look at why some people react to mosquito bites more than others.
Read more → TraitA 2010 study of Filipino women found a variant in CPS1 that raises homocysteine only in females, plus a much stronger MTHFR effect in young adults than in their mothers.
Read more → ConditionA 2018 meta-analysis of over 200,000 people found 41 risk loci for allergic rhinitis — hay fever — including fine-mapped positions in the HLA region tied to how the immune system recognizes allergens.
Read more → TraitA 2010 meta-analysis of up to 122,744 people without diabetes found 16 loci shaping fasting glucose as a continuous measurement — related to, but distinct from, the diagnosis of type 2 diabetes.
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One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.