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OPRM1

OPRM1 is a gene. This site has 14 published variants inside it and 3 near it, each from a published genetic study, joining it to 9 condition pages and 1 drug page.

Medicines it changes

• Opioids · Analgesic

What prescribing experts say about OPRM1 (15)

CPIC, the international group that writes gene-based prescribing guidelines, rates how strong the evidence is for each gene and medicine, from A (strong enough to change the prescription) to D (weak or conflicting). Every rating is shown, the weak ones included, so you can see where the evidence stops.

• alfentanil · level C: not enough to change the prescription
• buprenorphine · level C: not enough to change the prescription
• codeine · level C: not enough to change the prescription
• fentanyl · level C: not enough to change the prescription
• hydrocodone · level C: not enough to change the prescription
• hydromorphone · level C: not enough to change the prescription
• levomethadone · level C: not enough to change the prescription
• methadone · level C: not enough to change the prescription
• morphine · level C: not enough to change the prescription
• naloxone · level C: not enough to change the prescription (provisional)
• naltrexone · level C: not enough to change the prescription
• oxycodone · level C: not enough to change the prescription
• remifentanil · level C: not enough to change the prescription
• sufentanil · level C: not enough to change the prescription
• tramadol · level C: not enough to change the prescription

Source: CPIC (Clinical Pharmacogenetics Implementation Consortium), public domain (CC0), copy kept on this site and refreshed weekly.

Conditions it is linked to

• Celiac Disease
• Childhood Body Mass Index
• Gout
• Height
• Obesity and Body Weight
• Opioid Receptor Sensitivity (OPRM1)
• Opioid Use Disorder
• Type 2 Diabetes
• Waist-to-Hip Ratio (Body Fat Distribution)

Variants inside OPRM1 (14)

• rs1294093 · Body mass index
• rs3778150 · Height
• rs79910351 · Height
• rs13193545 · Insulin-like growth factor 1 levels
• rs17181171 · Menstruation quality of life impact (fever)
• rs73568641 · Methadone dose in opioid dependence
• rs9478500 · Opioid addiction (multi-trait analysis)
• rs1799971 · Opioid receptor sensitivity
• rs3778151 · Opioid use disorder
• rs696523 · Testosterone levels
• rs7773995 · Total testosterone levels
• rs3778156 · Type 2 diabetes
• rs9688977 · Weight
• rs514980 · Whole body water mass (UKB data field 23102)

Variants near OPRM1 (3)

Positions outside the gene, filed under it because it is the closest. A variant near a gene does not always act through it.

• rs114329900 · BMI (standard GWA)
• rs1772945 · BMI at 8 months old
• rs10499276 · Body mass index

See OPRM1 with everything it connects to on the Gene Knowledge Graph, or as data at /api/v1/genes/OPRM1.

A gene page gathers published research; it is not a test result and not medical advice. If a gene matters to your health, talk to a doctor or a genetic counsellor.