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Total testosterone levels

OPRM1 · rs7773995

Where this position leads

Drug: Opioids

rs7773995 Drug: Opioids Opioids Drug rs7773995 rs7773995 OPRM1

What the study found

Who was studied 194,453 European ancestry men.

The effect Each copy of the C allele shifted the measure 0.0236 higher (95% confidence interval 0.016-0.032); p = 1 × 10−9.

How common The C allele had a frequency of about 83% in the people studied.

Where it sits Chromosome 6, band 6q25.2 — in an intron of OPRM1.

What each result means

C/C Two copies of the version the research linked to Total testosterone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Total testosterone levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Total testosterone levels. This is the starting point the study compared everyone against.
Source

Questions about rs7773995

What is rs7773995?

rs7773995 is a single position in the genome, in or near the OPRM1 gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs7773995 affect how medicines work?

OPRM1 carries pharmacogenomic findings for Opioids. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs7773995 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7773995 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total testosterone levels (rs7773995). MyGeneLog™. https://www.mygenelog.com/variants/rs7773995

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