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Who was studied 243,951 European and South Asian ancestry males.
The effect
Each copy of the C allele shifted the measure 0.0224 lower (95% confidence interval 0.015-0.029); p = 7 × 10−10.
How common The C allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 6, band 6q25.2 — in an intron of OPRM1.
What each result means
A/ANo copy of the version the research linked to Testosterone levels. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Testosterone levels. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Testosterone levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 40229599 · open access
Questions about rs696523
What is rs696523?
rs696523 is a single position in the genome, in or near the OPRM1 gene. Published research associates it with testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs696523 affect how medicines work?
OPRM1 carries pharmacogenomic findings for Opioids. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs696523 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs696523 come from?
GWAS Catalog, Nature genetics 2025, PMID:40229599. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 197210Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot7Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others10Total19Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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