← Drugs

Analgesic

Opioids

One of the most studied genes in all of pharmacogenomics sits here — and the guideline that reviewed it concluded that no dosing recommendation can be made. That conclusion is the finding.

Share:

The genes involved

OPRM1

Opioid Receptor Sensitivity (OPRM1) →

CPIC reviewed OPRM1 rs1799971 (A118G) for opioid therapy and issued no dosing recommendation. Some studies show a small (~10%) increase in postoperative morphine dose requirements in G-allele carriers, but CPIC concluded this effect is too modest to be clinically actionable. CPIC level C (insufficient evidence for a recommendation).

Crews KR, et al. Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy. Clin Pharmacol Ther. 2021;109(6):1420-1425. PMID 33387367.

Variants MyGeneLog reports for these genes

These are the positions in your own file that carry the genes above. Not every gene in a guideline is one we report — where that is the case the gene appears above without a variant here, and the note says so.

Opioid receptor sensitivity

OPRM1 · rs1799971

Read more →
This page is educational and contains no dosing information. Where a clinical guideline covers one of these gene-drug pairs it is written for prescribers and works through validated algorithms alongside clinical monitoring. Nothing here is a reason to start, stop, or change a medication — that conversation belongs with the clinician or pharmacist managing your treatment.