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Weight

OPRM1 · rs9688977

Where this position leads

Condition: Obesity and Body Weight

Drug: Opioids

rs9688977 Condition: Obesity and Body Weight Obesity and Body Weight Condition Drug: Opioids Opioids Drug rs9688977 rs9688977 OPRM1

What the study found

Who was studied 360,116 European ancestry individuals, 165,419 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0196 higher (95% confidence interval 0.014-0.025); p = 6 × 10−13.

Where it sits Chromosome 6, band 6q25.2 — in an intron of OPRM1.

What each result means

C/C Two copies of the version the research linked to Weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Weight. That is a smaller link than two copies.
T/T No copy of the version the research linked to Weight. This is the starting point the study compared everyone against.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs9688977

What is rs9688977?

rs9688977 is a single position in the genome, in or near the OPRM1 gene. Published research associates it with weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9688977 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does rs9688977 affect how medicines work?

OPRM1 carries pharmacogenomic findings for Opioids. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9688977 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9688977 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Weight (rs9688977). MyGeneLog™. https://www.mygenelog.com/variants/rs9688977

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