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Opioid Use Disorder, as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 37,761 cases and 409,760 controls (African American ancestry, European ancestry, Hispanic ancestry, African ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Opioid Use Disorder — filed in the GWAS Catalog as "Opioid use disorder" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 4 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Kember RL et al. 2022, in Nature Neuroscience — Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. The catalogue records its sample as 37,761 cases and 409,760 controls (African American ancestry, European ancestry, Hispanic ancestry, African ancestry). The 4 positions on this page from it: rs3778151 (OPRM1), rs1831060692 (RABEPK), rs112068658 (KCNN1), rs76450220 (near LINC00581). PMID:36171425.
The 4 positions lie in or near 4 genes: OPRM1, RABEPK, KCNN1, LINC00581. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Of all these, rs3778151 in OPRM1 carries the strongest signal: P = 9 × 10-11, in Kember RL et al. 2022.
It is a record of what genome-wide studies have reported about Opioid Use Disorder, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Nothing on this page diagnoses Opioid Use Disorder. The 4 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
Databases, guidelines and references
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Opioid Use Disorder. MyGeneLog™. https://www.mygenelog.com/conditions/opioid-use-disorder
Opioid Use Disorder is the condition the GWAS Catalog files under "Opioid use disorder". This page does not define it in its own words; it lists what genome-wide studies have reported: 4 positions from 1 study, with each study's sample and citation.
Genes play a part: 4 positions have been linked to it, the largest study recording 37,761 cases and 409,760 controls (African American ancestry, European ancestry, Hispanic ancestry, African ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 4 genes: OPRM1, RABEPK, KCNN1, LINC00581. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Opioid Use Disorder from a genotype; a clinician diagnoses it.
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