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Methadone dose in opioid dependence

OPRM1 · rs73568641

Where this position leads

Condition: Opioid Receptor Sensitivity (OPRM1)

Drug: Opioids

rs73568641 Condition: Opioid Receptor Sensitivity (OPRM1) Opioid Receptor Sensitivity (OPRM1) Condition Drug: Opioids Opioids Drug rs73568641 rs73568641 OPRM1

What the study found

Who was studied 1,027 European American cases, 383 African American cases.

The effect Each copy of the C allele shifted the measure 0.681 higher (95% confidence interval 0.44-0.92); p = 3 × 10−8.

How common The C allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 6, band 6q25.2 — between genes, 22.5 kb from RNU6-896P.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Methadone dose in opioid dependence compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Methadone dose in opioid dependence.
T/T Published research associates this genotype with typical/baseline likelihood of Methadone dose in opioid dependence — no copies of the reported risk allele.
Source
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1
Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J
Molecular psychiatry · 2017 · PMID 28115739

Questions about rs73568641

What is rs73568641?

rs73568641 is a single position in the genome, in or near the OPRM1 gene. Published research associates it with methadone dose in opioid dependence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs73568641 linked to?

On MyGeneLog this position is linked to Opioid Receptor Sensitivity (OPRM1). The research behind each link, and its sources, are set out on that condition page.

Does rs73568641 affect how medicines work?

OPRM1 carries pharmacogenomic findings for Opioids. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs73568641 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs73568641 come from?

GWAS Catalog, Mol Psychiatry 2017, PMID:28115739. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Methadone dose in opioid dependence (rs73568641). MyGeneLog™. https://www.mygenelog.com/variants/rs73568641

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