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Who was studied 394,642 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.00903 higher (95% confidence interval 0.0061-0.012); p = 1 × 10−11.
How common The C allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 6, band 6q25.2 — in an intron of OPRM1.
What each result means
C/CTwo copies of the version the research linked to Whole body water mass (UKB data field 23102). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Whole body water mass (UKB data field 23102). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Whole body water mass (UKB data field 23102). This is the starting point the study compared everyone against.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs514980
What is rs514980?
rs514980 is a single position in the genome, in or near the OPRM1 gene. Published research associates it with whole body water mass (ukb data field 23102). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs514980 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs514980 affect how medicines work?
OPRM1 carries pharmacogenomic findings for Opioids. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs514980 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs514980 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 6123Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Whole body water mass (UKB data field 23102) (rs514980). MyGeneLog™. https://www.mygenelog.com/variants/rs514980