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Who was studied 1,122,049 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.011 lower (95% confidence interval 0.0075-0.0145); p = 1 × 10−9.
Where it sits Chromosome 6, band 6q25.2 — in an intron of OPRM1.
What each result means
A/ANo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 36581621 · open access
Questions about rs1294093
What is rs1294093?
rs1294093 is a single position in the genome, in or near the OPRM1 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1294093 linked to?
On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.
Does rs1294093 affect how medicines work?
OPRM1 carries pharmacogenomic findings for Opioids. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs1294093 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1294093 come from?
GWAS Catalog, Nature communications 2022, PMID:36581621. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs1294093). MyGeneLog™. https://www.mygenelog.com/variants/rs1294093