0 211Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others1Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 8,968 African American cases, 79,530 African American controls, 24,867 European ancestry cases, 296,446 European ancestry controls, 2,527 Hispanic American cases, 32,334 Hispanic American controls, 1,399 African ancestry cases, 1,450 African ancestry controls.
The effect
Each copy of the T allele shifted the measure 6.49 z score lower; p = 9 × 10−11.
Where it sits Chromosome 6, band 6q25.2 — in an intron of OPRM1.
What each result means
C/CNo copy of the version the research linked to Opioid use disorder. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Opioid use disorder. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Opioid use disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs3778151 is a single position in the genome, in or near the OPRM1 gene. Published research associates it with opioid use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs3778151 affect how medicines work?
OPRM1 carries pharmacogenomic findings for Opioids. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs3778151 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3778151 come from?
GWAS Catalog, Nature neuroscience 2022, PMID:36171425. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 211Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others1Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Opioid use disorder (rs3778151). MyGeneLog™. https://www.mygenelog.com/variants/rs3778151