Hippocampal Atrophy, as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 1,149 cases, 188 controls, 336 individuals (European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Hippocampal Atrophy — filed in the GWAS Catalog as "Hippocampal atrophy" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 2 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Melville SA et al. 2012, in Annals of Neurology — Multiple loci influencing hippocampal degeneration identified by genome scan. The catalogue records its sample as 1,149 cases, 188 controls, 336 individuals (European ancestry). The 2 positions on this page from it: rs6703865 (SELP), rs2298948 (GCFC2). PMID:22745009.
The catalogue maps the 2 positions to 2 genes: SELP, GCFC2. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs6703865 in SELP carries the strongest signal: P = 10-9, in Melville SA et al. 2012.
It is a record of what genome-wide studies have reported about Hippocampal Atrophy, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Hippocampal Atrophy is diagnosed by a clinician — not from a genotype. None of the 2 variants on this page is used by any guideline to predict, screen for or diagnose it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Hippocampal Atrophy comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hippocampal Atrophy. MyGeneLog™. https://www.mygenelog.com/conditions/hippocampal-atrophy
Hippocampal Atrophy is the condition the GWAS Catalog files under "Hippocampal atrophy". This page does not define it in its own words; it lists what genome-wide studies have reported: 2 positions from 1 study, with each study's sample and citation.
Genes play a part: 2 positions have been linked to it, the largest study recording 1,149 cases, 188 controls, 336 individuals (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 2 genes: SELP, GCFC2. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Hippocampal Atrophy is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.