Meniere's Disease, as genome-wide studies have reported it: 10 positions from 3 studies, the largest recording 8,900 cases and 1,881,340 controls (European ancestry, East Asian ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Genome-wide studies have so far placed 10 positions on Meniere's Disease, from 3 studies; the GWAS Catalog files the condition as "Meniere's disease (PheCode 386.1)". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 2,306 cases and 507,752 controls (Hispanic or Latin American ancestry, European ancestry). From it, 7 positions on this page: rs75323670 (TRABD2B), rs76416960 (VPS13B), rs149479122 (PRDM11), rs553411385 (SLC37A3), rs979245270 (near RNU6-832P), rs533941215 (CAMK1D), rs115058055 (LINC01088). PMID:39024449.
Shi Z et al. 2026, in American Journal of Human Genetics — Genome-wide analysis implicates inner ear development in Ménière disease. The catalogue records its sample as 8,900 cases and 1,881,340 controls (European ancestry, East Asian ancestry, Hispanic or Latin American ancestry). From it, 2 positions on this page: rs3777811 (EYA4), rs61861121 (near XRCC6P1). PMID:42302782.
Sakaue S et al. 2021, in Nature Genetics — A cross-population atlas of genetic associations for 220 human phenotypes. Studied in 1,290 cases and 177,436 controls (East Asian ancestry). It contributes one position: rs529699157 (BRMS1L). PMID:34594039.
The 10 positions sit in or beside 10 genes: TRABD2B, VPS13B, PRDM11, SLC37A3, RNU6-832P, CAMK1D, LINC01088, EYA4, XRCC6P1, BRMS1L. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Of all these, rs3777811 in EYA4 carries the strongest signal: P = 10-17, with an odds ratio of 1.25, in Shi Z et al. 2026.
It is a record of what genome-wide studies have reported about Meniere's Disease, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
A genotype does not diagnose Meniere's Disease; a clinician does. No guideline uses the 10 variants on this page to predict it, screen for it or confirm it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Meniere's Disease comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Meniere's Disease. MyGeneLog™. https://www.mygenelog.com/conditions/menieres-disease
Meniere's Disease is the condition the GWAS Catalog files under "Meniere's disease (PheCode 386.1)". This page does not define it in its own words; it lists what genome-wide studies have reported: 10 positions from 3 studies, with each study's sample and citation.
Genome-wide studies have reported 10 associated positions; the largest study behind this page recorded 8,900 cases and 1,881,340 controls (European ancestry, East Asian ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 10 genes: TRABD2B, VPS13B, PRDM11, SLC37A3, RNU6-832P, CAMK1D, LINC01088, EYA4, XRCC6P1, BRMS1L. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Meniere's Disease from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.