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Infectious

COVID-19 with Respiratory Failure Requiring Mechanical Ventilation

Assembled from catalogue records October 14, 2026

COVID-19 with Respiratory Failure Requiring Mechanical Ventilation, as genome-wide studies have reported it: 3 positions from 1 study, the largest recording 13,052 cases and 1,438,150 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.

What this condition connects to

COVID-19 with Respiratory Failure Requiring Mechanical Ventilation Variant: rs77534576 rs77534576 Variant Variant: rs143334143 rs143334143 Variant Variant: rs2269899 rs2269899 Variant COVID-19 with Respiratory Failure Requiring Mechanical Ventilation COVID-19 with Respiratory Infectious
Prevalence
Not taken from these records, which report study sizes rather than how common the condition is. The largest study behind this page recorded 13,052 cases and 1,438,150 controls (European ancestry) (Degenhardt F et al. 2022, PMID:35848942).
Inheritance
Many positions, each with a small effect: 3 positions across 1 study, the pattern of a polygenic condition. The records do not give a heritability, and this page does not supply one.

1 study in the GWAS Catalog report 3 positions for COVID-19 with Respiratory Failure Requiring Mechanical Ventilation, which the catalogue files as "COVID-19 with respiratory failure requiring mechanical ventilation". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.

The studies behind the positions

Degenhardt F et al. 2022, in Human Molecular Genetics — Detailed stratified GWAS analysis for severe COVID-19 in four European populations. The catalogue records its sample as 13,052 cases and 1,438,150 controls (European ancestry). From it, 3 positions on this page: rs2269899 (OAS3), rs143334143 (CCHCR1), rs77534576 (near TAC4-AS1). PMID:35848942.

Positions and mapped genes

The 3 positions sit in or beside 3 genes: OAS3, CCHCR1, TAC4-AS1. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.

Degenhardt F et al. 2022 reported the smallest P value on this page — P = 8 × 10-14, with an odds ratio of 0.84 — at rs2269899 in OAS3.

What this page is, and is not

Read this page as a list of findings about COVID-19 with Respiratory Failure Requiring Mechanical Ventilation, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.

Clinical detail

What is actually diagnosed and treated here

Nothing on this page diagnoses COVID-19 with Respiratory Failure Requiring Mechanical Ventilation. The 3 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.

Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.

Related variants MyGeneLog™ checks for

What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about COVID-19 with Respiratory Failure Requiring Mechanical Ventilation comes down to these specific, well-studied positions — not a diagnosis.

Standard

COVID-19 with respiratory failure requiring mechanical ventilation

near TAC4-AS1 · rs77534576

See detailed info →
Standard

COVID-19 with respiratory failure requiring mechanical ventilation

CCHCR1 · rs143334143

See detailed info →
Standard

COVID-19 with respiratory failure requiring mechanical ventilation

OAS3 · rs2269899

See detailed info →

Sources

Databases, guidelines and references

Papers, with their authors
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB
and 317 more — show all
Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Blandino Ortiz A, de Salazar A, Garrido Chercoles A, Palom A, Ruiz A, Garcia-Fernandez AE, Blanco-Grau A, Mantovani A, Zanella A, Holten AR, Mayer A, Bandera A, Cherubini A, Protti A, Aghemo A, Gerussi A, Ramirez A, Braun A, Nebel A, Barreira A, Lleo A, Teles A, Kildal AB, Biondi A, Caballero-Garralda A, Ganna A, Gori A, Glück A, Lind A, Tanck A, Hinney A, Carreras Nolla A, Fracanzani AL, Peschuck A, Cavallero A, Dyrhol-Riise AM, Ruello A, Julià A, Muscatello A, Pesenti A, Voza A, Rando-Segura A, Solier A, Schmidt A, Cortes B, Mateos B, Nafria-Jimenez B, Schaefer B, Jensen B, Bellinghausen C, Maj C, Ferrando C, de la Horra C, Quereda C, Skurk C, Thibeault C, Scollo C, Herr C, Spinner CD, Gassner C, Lange C, Hu C, Paccapelo C, Lehmann C, Angelini C, Cappadona C, Azuure C, Bianco C, Cea C, Sancho C, Hoff DAL, Galimberti D, Prati D, Haschka D, Jiménez D, Pestaña D, Toapanta D, Muñiz-Diaz E, Azzolini E, Sandoval E, Binatti E, Scarpini E, Helbig ET, Casalone E, Urrechaga E, Paraboschi EM, Pontali E, Reverter E, Calderón EJ, Navas E, Solligård E, Contro E, Arana-Arri E, Aziz F, Garcia F, García Sánchez F, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Kurth F, Blasi F, Malvestiti F, Medrano FJ, Mesonero F, Rodriguez-Frias F, Hanses F, Müller F, Hemmrich-Stanisak G, Bellani G, Grasselli G, Pezzoli G, Costantino G, Albano G, Cardamone G, Bellelli G, Citerio G, Foti G, Lamorte G, Matullo G, Baselli G, Kurihara H, Neb H, My I, Kurth I, Hernández I, Pink I, de Rojas I, Galván-Femenia I, Holter JC, Afset JE, Heyckendorf J, Kässens J, Damås JK, Rybniker J, Altmüller J, Ampuero J, Martín J, Erdmann J, Banales JM, Badia JR, Dopazo J, Schneider J, Bergan J, Barretina J, Walter J, Hernández Quero J, Goikoetxea J, Delgado J, Guerrero JM, Fazaal J, Kraft J, Schröder J, Risnes K, Banasik K, Müller KE, Gaede KI, Garcia-Etxebarria K, Tonby K, Heggelund L, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Sander LE, Lippert LJ, Terranova L, Nkambule L, Knopp L, Gustad LT, Garbarino L, Santoro L, Téllez L, Roade L, Ostadreza M, Intxausti M, Kogevinas M, Riveiro-Barciela M, Berger MM, Schaefer M, Niemi MEK, Gutiérrez-Stampa MA, Carrabba M, Figuera Basso ME, Valsecchi MG, Hernandez-Tejero M, Vehreschild MJGT, Manunta M, Acosta-Herrera M, D'Angiò M, Baldini M, Cazzaniga M, Grimsrud MM, Cornberg M, Nöthen MM, Marquié M, Castoldi M, Cordioli M, Cecconi M, D'Amato M, Augustin M, Tomasi M, Boada M, Dreher M, Seilmaier MJ, Joannidis M, Wittig M, Mazzocco M, Ciccarelli M, Rodríguez-Gandía M, Bocciolone M, Miozzo M, Imaz Ayo N, Blay N, Chueca N, Montano N, Braun N, Ludwig N, Marx N, Martínez N, Cornely OA, Witzke O, Palmieri O, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, España PP, Hoffmann P, Rosenstiel P, Schommers P, Suwalski P, de Pablo R, Ferrer R, Bals R, Gualtierotti R, Gallego-Durán R, Nieto R, Carpani R, Morilla R, Badalamenti S, Haider S, Ciesek S, May S, Bombace S, Marsal S, Pigazzini S, Klein S, Pelusi S, Wilfling S, Bosari S, Volland S, Brunak S, Raychaudhuri S, Schreiber S, Heilmann-Heimbach S, Aliberti S, Ripke S, Dudman S, Wesse T, Zheng T, Bahmer T, Eggermann T, Illig T, Brenner T, Pumarola T, Feldt T, Folseraas T, Gonzalez Cejudo T, Landmesser U, Protzer U, Hehr U, Rimoldi V, Monzani V, Skogen V, Keitel V, Kopfnagel V, Friaza V, Andrade V, Moreno V, Albrecht W, Peter W, Poller W, Farre X, Yi X, Wang X, Khodamoradi Y, Karadeniz Z, Latiano A, Goerg S, Bacher P, Koehler P, Tran F, Zoller H, Schulte EC, Heidecker B, Ludwig KU, Fernández J, Romero-Gómez M, Albillos A, Invernizzi P, Buti M, Duga S, Bujanda L, Hov JR, Lenz TL, Asselta R, de Cid R, Valenti L, Karlsen TH, Cáceres M, Franke A
COVICAT study group, Aachen Study (COVAS) · Norwegian SARS-CoV-2 Study group · Pa Study Group · STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force
Human molecular genetics · 2022 · PMID 35848942 · open access

Quoting this page

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COVID-19 with Respiratory Failure Requiring Mechanical Ventilation. MyGeneLog™. https://www.mygenelog.com/conditions/covid-19-with-respiratory-failure-requiring-mechanical-ventilation

Questions about COVID-19 with Respiratory Failure Requiring Mechanical Ventilation

What is COVID-19 with Respiratory Failure Requiring Mechanical Ventilation?

COVID-19 with Respiratory Failure Requiring Mechanical Ventilation is the condition the GWAS Catalog files under "COVID-19 with respiratory failure requiring mechanical ventilation". This page does not define it in its own words; it lists what genome-wide studies have reported: 3 positions from 1 study, with each study's sample and citation.

Is COVID-19 with Respiratory Failure Requiring Mechanical Ventilation genetic?

Genes play a part: 3 positions have been linked to it, the largest study recording 13,052 cases and 1,438,150 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.

Which genes are linked to COVID-19 with Respiratory Failure Requiring Mechanical Ventilation on this page?

The catalogue maps the positions to 3 genes: OAS3, CCHCR1, TAC4-AS1. These are where the positions sit, not proof of how they act.

Can these variants predict whether I will get COVID-19 with Respiratory Failure Requiring Mechanical Ventilation?

No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts COVID-19 with Respiratory Failure Requiring Mechanical Ventilation from a genotype; a clinician diagnoses it.

Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.