Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
33 results in Cardiovascular
People living with HIV on antiretroviral therapy face elevated cardiovascular risk. A small study of 177 men on HAART found a variant in RYR3 — a gene that regulates calcium release in vessel-wall muscle — associated with an early ultrasound marker of artery narrowing, reported honestly as a first finding rather than a settled one.
Read more → CardiovascularA heart attack: the moment a coronary artery closes, rather than the years it spends narrowing. Four variants come from the largest case-control study of its time; a fifth was found by watching healthy people prospectively for who had a first one.
Read more → CardiovascularAtherosclerosis narrowing the arteries outside the heart and brain, usually in the legs. This page holds a variant from the first study to find any genetic risk factors for it at all — and the study went as far as showing the risk version of the DNA lowers its nearby gene's activity in the lab.
Read more → CardiovascularFibrinogen is one of the oldest predictors of heart disease there is, and a third to a half of the difference between people is inherited. Genetics has found more than forty places that move it — and no strong evidence that moving it changes cardiovascular risk at all.
Read more → CardiovascularNearly a hundred positions here move cholesterol, and each one moves it a little. The two things worth knowing are that very high LDL almost never has a single-gene cause — fewer than 2 in 100 do — and that genetics worked out the HDL hypothesis was wrong years before the drug trials confirmed it.
Read more → CardiovascularA genome-wide scan of venous thrombosis found no new genes at all. That is the result worth reporting: the four loci already known account for what common variants explain, and one of them is your blood group.
Read more → CardiovascularThe largest meta-analysis of stroke genetics found that the loci belong to subtypes rather than to stroke. A clot from the heart and a blocked neck artery are different diseases that end in the same emergency.
Read more → CardiovascularCRP is one of the best predictors of cardiovascular events in the blood, and the genetics is the reason we know it is not a cause. Variants that raise CRP for life do not raise heart disease — which is exactly the test a marker has to fail to be demoted from a cause.
Read more → CardiovascularThe positions here were found by asking three different questions — who develops furred arteries, who has a heart attack early, and who has a heart attack given furred arteries. The answers were not the same genes, which is the most useful thing this page has to say.
Read more → CardiovascularMore than two thousand positions have been linked to blood pressure and together they still lose to a cuff on your arm. Two of the three here came from an east Asian study — unusual on a site whose evidence is mostly European — and two of them sit in the same gene, found on different continents by groups asking different questions.
Read more → CardiovascularCommon variants move the heart's recovery time by a millisecond or two — nothing on their own. They start to matter when a medicine pushes in the same direction, which several hundred medicines do.
Read more → CardiovascularCommon variants near the APOA5 gene are associated with modestly higher average triglyceride levels. They contribute a small shift, not a diagnosis, and very high triglycerides mainly matter because of pancreatitis risk.
Read more → CardiovascularA common DNA variant near the PITX2 gene is the strongest and most consistently replicated genetic risk factor for atrial fibrillation, the most common irregular heart rhythm and a major cause of stroke.
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One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.