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Conditions

4

Crohn's Disease A lifelong inflammatory bowel disease that can affect any part of the digestive tract. Its genetics are unusually well mapped — NOD2 was th… Knee Osteoarthritis For a century this was "wear and tear" — a joint used until it wore out. Then a scan of 4,800 people found its strongest signal in the immu… Rheumatoid Arthritis An autoimmune disease that attacks the lining of joints. The variant here sits in a small stretch of chromosome 6 that turned out to hold t… Type 1 Diabetes An autoimmune disease that destroys the cells making insulin. It shares a word with type 2 diabetes and almost nothing else — different age…

Variants

9

rs10947262 HLA-DQA2 — Knee osteoarthritis rs12525220 HLA-DQA2 — Rheumatoid arthritis rs1799964 HLA-DQA2 — Crohn's disease rs2858331 HLA-DQA2 — IgE levels rs2858884 HLA-DQA2 — Narcolepsy rs35122968 HLA-DQA2 — Type 1 diabetes (age at diagnosis)

Topics

10

Infection and immunity Whether an infection passes or stays is decided as much by the host as by the microbe — and the host genes that decide it are usually the o… Liver The organ people only think about when a blood test comes back odd. Two of its commonest numbers are partly inherited, which is why a raise… Fertility Genetics has a great deal to say about the timing of reproduction across populations and almost nothing to say to one person trying to conceive. Bones and fractures Bone density is one of the more heritable things about a body — and the thing that actually matters, whether it breaks, is much harder to p… Alcohol and the flush One of the few places where a single variant is visible in the mirror. Exercise and muscle The "sprinter gene" is the most oversold result in consumer genetics.