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Conditions

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ADHD (Attention Deficit Hyperactivity Disorder) One of the most heritable common conditions there is — and one of the least predictable from a genome. Twin studies put the inherited share… Breast Cancer The genetics that changes what anyone does about breast cancer is BRCA1 and BRCA2 — rare, strong, and tested for properly. The variants her…

Variants

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rs10994359 ANK3 — Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (… rs11591402 SORCS3 — ADHD susceptibility (SORCS3) rs1427829 DUSP6 — ADHD susceptibility (near DUSP6) rs1592757 ADHD susceptibility (chromosome 5q21) rs2243517 RNF219-AS1 — ADHD susceptibility (RNF219-AS1) rs3001723 PTPRF — ADHD susceptibility (PTPRF)

Drugs

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Atomoxetine A genotype here changes the dose, not the diagnosis. Nothing about ADHD is decided by a gene test, and the guideline is about exposure. Combined hormonal contraceptives A case where two risks multiply rather than add. Estrogen raises clot risk on its own; in someone who also carries a thrombophilia variant …

Topics

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Anxiety and worry The largest study of the trait behind this found it was not one trait. “Worry” and “depressed affect” came apart in the data, which is a fi… ADHD and attention Diagnoses are rising fast; the genetics is real and highly polygenic.

For classrooms

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Lesson: when genetic findings don't apply to other populations A free lesson on reading data critically, using this site as the dataset. The class computes the same prediction in five populations and me… Lesson: why one broken gene copy costs 94% of an enzyme A free chemistry lesson with one coin per student. Ask a class what one broken copy of a gene out of two costs you and they will say half. …

Updates

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The Genes Your Parents Didn't Pass On Still Predicted Your Schooling Three million genomes, 3,952 variants, and a result so strange it changes what the whole field means: the DNA your parents did not pass on …