Sensitive

Type 1 diabetes (age at diagnosis)

HLA-DQA2 · rs35122968

Where this position leads

Condition: Type 1 Diabetes

rs35122968 Condition: Type 1 Diabetes Type 1 Diabetes Condition rs35122968 rs35122968 HLA-DQA2

What the study found

Who was studied 12,539 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.2 higher (95% confidence interval 0.14-0.26); p = 4 × 10−11.

How common The C allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 3.6 kb from LOC102725019.

What each result means

C/C Two copies of the version the research linked to Type 1 diabetes (age at diagnosis). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Type 1 diabetes (age at diagnosis). That is a smaller link than two copies.
T/T No copy of the version the research linked to Type 1 diabetes (age at diagnosis). This is the starting point the study compared everyone against.
Source

Questions about rs35122968

What is rs35122968?

rs35122968 is a single position in the genome, in or near the HLA-DQA2 gene. Published research associates it with type 1 diabetes (age at diagnosis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35122968 linked to?

On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs35122968 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35122968 come from?

GWAS Catalog, J Intern Med 2020, PMID:33179336. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 1 diabetes (age at diagnosis) (rs35122968). MyGeneLog™. https://www.mygenelog.com/variants/rs35122968

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