Start from a word, not an rsID

Topics

Everything else here starts from a variant. This starts from a topic — the kind of thing you would type into a search box — and asks which of our positions turn up in the same papers. A shared paper means somebody wrote about the two together. It is not a claim that the variant explains the topic, and for most of these the honest finding is that common variants explain very little of it.

Smoking and vaping

How hard quitting is turns out to be partly a metabolic question.

21 variants · 134 papers

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Exercise and muscle

The "sprinter gene" is the most oversold result in consumer genetics.

98 variants · 353 papers

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Running and endurance

Running clubs, first marathons, and a watch telling you your VO2max.

14 variants · 73 papers

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ADHD and attention

Diagnoses are rising fast; the genetics is real and highly polygenic.

26 variants · 50 papers

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Depression and stress

The field that taught genetics its hardest lesson about single genes.

57 variants · 221 papers

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Alcohol and the flush

One of the few places where a single variant is visible in the mirror.

103 variants · 452 papers

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Caffeine and energy drinks

The most-consumed drug on earth, metabolised at wildly different speeds.

27 variants · 95 papers

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Sleep and insomnia

Why some people wake at 5am without an alarm and others cannot.

42 variants · 79 papers

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Weight-loss medicines

GLP-1 drugs made obesity genetics a dinner-table subject.

9 variants · 19 papers

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Risk-taking and impulsivity

Trading, betting, and every "should I?" at 2am. Over a million people were studied: 99 positions turned up, 46 of them shared with risky behaviour in driving, drinking, smoking or sex — one disposition showing through in several places at once. And none of the genes previously famous for this survived.

14 variants · 29 papers

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Cholesterol and blood fats

The one axis here where a common variant can move a number a clinic already measures. Lipid levels are among the most heritable ordinary measurements in medicine — which is not the same as saying a genotype tells you what yours is.

127 variants · 439 papers

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Heart and circulation

Three different questions wear the same word. Who furs their arteries, who has a heart attack early, and whose heart falls out of rhythm are separate problems with separate genetics — and this site keeps them on separate pages for that reason.

230 variants · 908 papers

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Blood sugar and insulin

The most-studied common disease there is, and the one where the gap between what genetics found and what changes an outcome is widest. Hundreds of positions are associated with type 2 diabetes; together they predict less about who develops it than a waist measurement and a family history do.

296 variants · 1479 papers

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Questions about topics on this site

What is a "topic" page on this site?

A subject people actually search for — sleep, running, personality — paired with the variants that share a published paper with it, counted in Europe PMC.

Does a topic page mean genetics explains that subject?

No. A shared paper means researchers wrote about the topic and the variant together, not that the variant explains the topic — and for most of these, common variants explain very little of it.

How is the variant list for a topic counted?

Europe PMC is searched for that topic’s specific terms appearing in a paper’s title or abstract alongside a published rsID. Full text is deliberately excluded — it returns papers with an rsID buried in a supplementary table, not papers about the topic.

How often does the topic list change?

Recounted monthly, and the topic list itself is revised when the conversation moves — a subject that stops being talked about stops earning a place on it.