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A/ANeither copy carries the associated allele at this position. The signal sits in an intron near DUSP6, a phosphatase that switches off part of the MAP-kinase signalling cascade and has been linked to dopamine levels in the brain — the system that ADHD medicines act on. On its own this says almost nothing about anyone: the effect of this position is a few percent, and ADHD involves thousands of positions plus a great deal that is not genetic.
A/GOne copy of the associated allele. Roughly half of people carry it: about 56% in Europe, 59% in East Asia, 25% in Africa. The measured effect is a small shift in the odds across a population of tens of thousands of people — not something that shows up in one person.
G/GTwo copies of the associated allele. Still a small shift, and still not a finding an individual can act on. The reason to record it is what it points at biologically, not what it predicts.
ADHD is diagnosed by a clinician from behaviour observed in more than one setting, over time. No genotype contributes to that assessment, and nothing at this position rules the diagnosis in or out.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs1427829
What is rs1427829?
rs1427829 is a single position in the genome, in or near the DUSP6 gene. Published research associates it with adhd susceptibility (near dusp6). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1427829 linked to?
On MyGeneLog this position is linked to ADHD (Attention Deficit Hyperactivity Disorder). The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs1427829?
Subjects that appear in the title or abstract of the same papers as this rsID include adhd and attention (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1427829 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1427829 come from?
Demontis et al., Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder, Nature Genetics 2019 (PMID 30478444) — meta-analysis of 20,183 diagnosed individuals and 35,191 controls. Position and alleles checked against Ensembl (GRCh38). Reported P = 7e-9. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 5532927122225Reads by AI crawlersClaude3ChatGPT2Google · Gemini9Perplexity2Meta AI7Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others25Total55Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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