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Omega-3 Fatty Acids to Polyunsaturated Fatty Acids percentage

CYP2C9 · rs9332238

Where this position leads

Condition: Age-Related Macular Degeneration

Drugs: Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin

rs9332238 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition Drug: Acenocoumarol and phenprocoumon Acenocoumarol and phenprocoumon Drug Drug: NSAIDs NSAIDs Drug Drug: Phenytoin and fosphenytoin Phenytoin and fosphenytoin Drug Drug: Siponimod Siponimod Drug Drug: Statins Statins Drug Drug: Sulfonylureas Sulfonylureas Drug Drug: Warfarin Warfarin Drug rs9332238 rs9332238 CYP2C9

What the study found

Who was studied 98,316 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.111 higher (95% confidence interval 0.074-0.148); p = 1 × 10−9.

How common The A allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of CYP2C9.

What each result means

A/A Two copies of the version the research linked to Omega-3 Fatty Acids to Polyunsaturated Fatty Acids percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Omega-3 Fatty Acids to Polyunsaturated Fatty Acids percentage. That is a smaller link than two copies.
G/G No copy of the version the research linked to Omega-3 Fatty Acids to Polyunsaturated Fatty Acids percentage. This is the starting point the study compared everyone against.
Source

Questions about rs9332238

What is rs9332238?

rs9332238 is a single position in the genome, in or near the CYP2C9 gene. Published research associates it with omega-3 fatty acids to polyunsaturated fatty acids percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9332238 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does rs9332238 affect how medicines work?

CYP2C9 carries pharmacogenomic findings for Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9332238 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9332238 come from?

GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Omega-3 Fatty Acids to Polyunsaturated Fatty Acids percentage (rs9332238). MyGeneLog™. https://www.mygenelog.com/variants/rs9332238

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