Pelvic Organ Prolapse, as genome-wide studies have reported it: 7 positions from 2 studies, the largest recording 28,857 cases and 622,916 controls (Japanese ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Pelvic Organ Prolapse — filed in the GWAS Catalog as "Pelvic organ prolapse" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 7 positions from 2 studies, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Matsunami M et al. 2024, in Communications Biology — Genome-wide association studies for pelvic organ prolapse in the Japanese population. Studied in 28,857 cases and 622,916 controls (Japanese ancestry, European ancestry). From it, 5 positions on this page: rs4944936 (near RN7SKP297), rs4779863 (KLF13), rs251217 (SLC12A2), rs42400 (near LINC01020), rs12915554 (GREM1). PMID:39349682.
Pujol-Gualdo N et al. 2022, in Nature Communications — Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse. Studied in 28,086 cases and 546,291 controls (European ancestry). The 2 positions on this page from it: rs12325192 (near HNRNPA1L3), rs201194999 (near RNU2-40P). PMID:35739095.
The catalogue maps the 7 positions to 7 genes: RN7SKP297, KLF13, SLC12A2, LINC01020, GREM1, HNRNPA1L3, RNU2-40P. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs12325192 near HNRNPA1L3 carries the strongest signal: P = 10-21, with an odds ratio of 0.89, in Pujol-Gualdo N et al. 2022.
It is a record of what genome-wide studies have reported about Pelvic Organ Prolapse, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Pelvic Organ Prolapse is diagnosed by a clinician — not from a genotype. None of the 7 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Pelvic Organ Prolapse comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pelvic Organ Prolapse. MyGeneLog™. https://www.mygenelog.com/conditions/pelvic-organ-prolapse
Pelvic Organ Prolapse is the condition the GWAS Catalog files under "Pelvic organ prolapse". This page does not define it in its own words; it lists what genome-wide studies have reported: 7 positions from 2 studies, with each study's sample and citation.
Genes play a part: 7 positions have been linked to it, the largest study recording 28,857 cases and 622,916 controls (Japanese ancestry, European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 7 genes: RN7SKP297, KLF13, SLC12A2, LINC01020, GREM1, HNRNPA1L3, RNU2-40P. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Pelvic Organ Prolapse from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.