0 17142316Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others6Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 28,086 European ancestry cases, 546,291 European ancestry controls.
The effect
Each copy of the T allele carried 0.89 times the odds of Pelvic organ prolapse (95% confidence interval 0.87-0.91); p = 1 × 10−21.
How common The T allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 16, band 16q12.1 — between genes, 99.2 kb from HNRNPA1L3.
What each result means
C/CNo copy of the version the research linked to Pelvic organ prolapse. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Pelvic organ prolapse. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Pelvic organ prolapse. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 35739095 · open access
Questions about rs12325192
What is rs12325192?
rs12325192 is a single position in the genome, in or near the near HNRNPA1L3 gene. Published research associates it with pelvic organ prolapse. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12325192 linked to?
On MyGeneLog this position is linked to Pelvic Organ Prolapse. The research behind each link, and its sources, are set out on that condition page.
Does having rs12325192 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12325192 come from?
GWAS Catalog, Nature communications 2022, PMID:35739095. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 17142316Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI4Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others6Total17Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pelvic organ prolapse (rs12325192). MyGeneLog™. https://www.mygenelog.com/variants/rs12325192