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Pelvic organ prolapse

near LINC01020 · rs42400

Where this position leads

Condition: Pelvic Organ Prolapse

rs42400 Condition: Pelvic Organ Prolapse Pelvic Organ Prolapse Condition rs42400 rs42400 near LINC010…

What the study found

Who was studied 771 Japanese ancestry female cases, 76,625 Japanese ancestry female controls, 28,086 European ancestry cases, 546,291 European ancestry controls.

The effect Each copy of the C allele carried 1.07 times the odds of Pelvic organ prolapse (95% confidence interval 1.047-1.088); p = 2 × 10−11.

Where it sits Chromosome 5, band 5p15.32 — between genes, 9.2 kb from LINC01020.

What each result means

C/C Two copies of the version the research linked to Pelvic organ prolapse. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Pelvic organ prolapse. That is a smaller link than two copies.
G/G No copy of the version the research linked to Pelvic organ prolapse. This is the starting point the study compared everyone against.
Source

Questions about rs42400

What is rs42400?

rs42400 is a single position in the genome, in or near the near LINC01020 gene. Published research associates it with pelvic organ prolapse. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs42400 linked to?

On MyGeneLog this position is linked to Pelvic Organ Prolapse. The research behind each link, and its sources, are set out on that condition page.

Does having rs42400 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs42400 come from?

GWAS Catalog, Communications biology 2024, PMID:39349682. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pelvic organ prolapse (rs42400). MyGeneLog™. https://www.mygenelog.com/variants/rs42400

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