Standard

Pelvic organ prolapse

near RNU2-40P · rs201194999

Where this position leads

Condition: Pelvic Organ Prolapse

rs201194999 Condition: Pelvic Organ Prolapse Pelvic Organ Prolapse Condition rs201194999 rs201194999 near RNU2-40P

What the study found

Who was studied 28,086 European ancestry cases, 546,291 European ancestry controls.

The effect Each copy of the T allele carried 0.89 times the odds of Pelvic organ prolapse (95% confidence interval 0.85-0.93); p = 2 × 10−8.

How common The T allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 4, band 4q13.2 — between genes, 6.1 kb from RNU2-40P.

What each result means

C/C No copy of the version the research linked to Pelvic organ prolapse. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Pelvic organ prolapse. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Pelvic organ prolapse. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs201194999

What is rs201194999?

rs201194999 is a single position in the genome, in or near the near RNU2-40P gene. Published research associates it with pelvic organ prolapse. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs201194999 linked to?

On MyGeneLog this position is linked to Pelvic Organ Prolapse. The research behind each link, and its sources, are set out on that condition page.

Does having rs201194999 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs201194999 come from?

GWAS Catalog, Nature communications 2022, PMID:35739095. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pelvic organ prolapse (rs201194999). MyGeneLog™. https://www.mygenelog.com/variants/rs201194999

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