GREM1 · rs12915554
Where this position leads
Condition: Pelvic Organ Prolapse
What the study found
Who was studied 771 Japanese ancestry female cases, 76,625 Japanese ancestry female controls, 28,086 European ancestry cases, 546,291 European ancestry controls.
The effect Each copy of the C allele carried 1.06 times the odds of Pelvic organ prolapse (95% confidence interval 1.038-1.079); p = 9 × 10−9.
Where it sits Chromosome 15, band 15q13.3 — in the 3′ untranslated region of GREM1.
What ClinVar records
Classification
Benign for Hereditary cancer-predisposing syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2025-07-10.
ClinVar record 1282623 NM_013372.7(GREM1):c.*40C>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs12915554 is a single position in the genome, in or near the GREM1 gene. Published research associates it with pelvic organ prolapse. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Pelvic Organ Prolapse. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Communications biology 2024, PMID:39349682. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pelvic organ prolapse (rs12915554). MyGeneLog™. https://www.mygenelog.com/variants/rs12915554