Hay Fever And/or Eczema, as genome-wide studies have reported it: 13 positions from 2 studies, the largest recording 20,016 cases and 380,433 controls (European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Genome-wide studies have so far placed 13 positions on Hay Fever And/or Eczema, from 2 studies; the GWAS Catalog files the condition as "Hay fever and/or eczema". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Johansson Å et al. 2019, in Human Molecular Genetics — Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema. The catalogue records its sample as 84,034 cases and 239,773 controls (European ancestry). The 8 positions on this page from it: rs5743604 (TLR1), rs6881270 (IL7R), rs62404084 (HLA-DQA1), rs1444789 (near LINC02676), rs11255938 (near LINC02676), rs130071 (CCHCR1), rs7650683 (LPP), rs4616071 (near LAYN). PMID:31361310.
Grosche S et al. 2021, in Nature Communications — Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4. Sample in the catalogue's record: 20,016 cases and 380,433 controls (European ancestry). From it, 5 positions on this page: rs3848669 (RTEL1-TNFRSF6B), rs13208697 (near HLA-DQA1), rs2844594 (near WASF5P), rs4372325 (LINC02929), rs12334935 (near LINC02964). PMID:34785669.
The 13 positions sit in or beside 11 genes: TLR1, IL7R, HLA-DQA1, LINC02676, CCHCR1, LPP, LAYN, RTEL1-TNFRSF6B, WASF5P, LINC02929, LINC02964. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Johansson Å et al. 2019 reported the smallest P value on this page — P = 10-72, with an odds ratio of 1.15 — at rs5743604 in TLR1.
Association records say which positions differ, on average, between people with Hay Fever And/or Eczema and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Hay Fever And/or Eczema is diagnosed by a clinician — not from a genotype. None of the 13 variants on this page is used by any guideline to predict, screen for or diagnose it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Hay Fever And/or Eczema comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Hay Fever And/or Eczema. MyGeneLog™. https://www.mygenelog.com/conditions/hay-fever-and-or-eczema
In the GWAS Catalog, Hay Fever And/or Eczema is filed as "Hay fever and/or eczema". Rather than define it, this page lists the genome-wide findings: 13 positions from 2 studies, each with its study's sample and citation.
Genome-wide studies have reported 13 associated positions; the largest study behind this page recorded 20,016 cases and 380,433 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 11 genes: TLR1, IL7R, HLA-DQA1, LINC02676, CCHCR1, LPP, LAYN, RTEL1-TNFRSF6B, WASF5P, LINC02929, LINC02964. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Hay Fever And/or Eczema is diagnosed by a clinician, and no guideline uses a genotype to predict it.
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