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Eczema

IL7R · rs7709291

Where this position leads

What the study found

Who was studied 7,884 European ancestry cases, 239,773 European ancestry controls; replicated in 21,000 cases, 96,000 controls.

The effect Each copy of the G allele carried 1.11 times the odds of Eczema (95% confidence interval 1.078-1.149); p = 3 × 10⁻¹⁰.

How common The G allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 5, band 5p13.2 — between genes, 4.2 kb from IL7R.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Eczema — no copies of the reported risk allele.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Eczema.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Eczema compared to the general population.

Source

Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema

Johansson Å, Rask-Andersen M, Karlsson T, Ek WE

Human molecular genetics · 2019 · PMID 31361310 · open access

Questions about rs7709291

What is rs7709291?

rs7709291 is a single position in the genome, in or near the IL7R gene. Published research associates it with eczema. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7709291 linked to?

On MyGeneLog this position is linked to Hay Fever And/or Eczema. The research behind each link, and its sources, are set out on that condition page.

Does having rs7709291 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7709291 come from?

GWAS Catalog, Human molecular genetics 2019, PMID:31361310. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Eczema (rs7709291). MyGeneLog™. https://www.mygenelog.com/variants/rs7709291

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