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Eczema

LINC02929 · rs4372325

Where this position leads

Condition: Hay Fever And/or Eczema

rs4372325 Condition: Hay Fever And/or Eczema Hay Fever And/or Eczema Condition rs4372325 rs4372325 LINC02929

What the study found

Who was studied 20,016 European ancestry cases, 380,433 European ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 6 × 10−14.

How common The T allele had a frequency of about 38% in the people studied.

Where it sits Chromosome 10, band 10q21.2 — in an intron of LINC02929.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Eczema — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Eczema.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Eczema compared to the general population.
Source
Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4
Grosche S, Marenholz I, Esparza-Gordillo J, Arnau-Soler A, Pairo-Castineira E, Rüschendorf F, Ahluwalia TS, Almqvist C, Arnold A, Baurecht H, Bisgaard H, Bønnelykke K
and 50 more — show all
Brown SJ, Bustamante M, Curtin JA, Custovic A, Dharmage SC, Esplugues A, Falchi M, Fernandez-Orth D, Ferreira MAR, Franke A, Gerdes S, Gieger C, Hakonarson H, Holt PG, Homuth G, Hubner N, Hysi PG, Jarvelin MR, Karlsson R, Koppelman GH, Lau S, Lutz M, Magnusson PKE, Marks GB, Müller-Nurasyid M, Nöthen MM, Paternoster L, Pennell CE, Peters A, Rawlik K, Robertson CF, Rodriguez E, Sebert S, Simpson A, Sleiman PMA, Standl M, Stölzl D, Strauch K, Szwajda A, Tenesa A, Thompson PJ, Ullemar V, Visconti A, Vonk JM, Wang CA, Weidinger S, Wielscher M, Worth CL, Xu CJ, Lee YA
Australian Asthma Genetics Consortium (AAGC)
Nature communications · 2021 · PMID 34785669 · open access

Questions about rs4372325

What is rs4372325?

rs4372325 is a single position in the genome, in or near the LINC02929 gene. Published research associates it with eczema. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4372325 linked to?

On MyGeneLog this position is linked to Hay Fever And/or Eczema. The research behind each link, and its sources, are set out on that condition page.

Does having rs4372325 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4372325 come from?

GWAS Catalog, Nature communications 2021, PMID:34785669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Eczema (rs4372325). MyGeneLog™. https://www.mygenelog.com/variants/rs4372325

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