Gene Knowledge Graph
UTC
Standard

X-21849 levels

CYP2C9 · rs9332217

Where this position leads

Drugs: Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin

rs9332217 Drug: Acenocoumarol and phenprocoumon Acenocoumarol and phenprocoumon Drug Drug: NSAIDs NSAIDs Drug Drug: Phenytoin and fosphenytoin Phenytoin and fosphenytoin Drug Drug: Siponimod Siponimod Drug Drug: Statins Statins Drug Drug: Sulfonylureas Sulfonylureas Drug Drug: Warfarin Warfarin Drug rs9332217 rs9332217 CYP2C9

What the study found

Who was studied 14,296 European ancestry individuals; replicated in 5,698 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.254 lower (95% confidence interval 0.21-0.3); p = 7 × 10−31.

How common The A allele had a frequency of about 94% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of CYP2C9.

What each result means

A/A Two copies of the version the research linked to X-21849 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to X-21849 levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to X-21849 levels. This is the starting point the study compared everyone against.
Source
Rare and common genetic determinants of metabolic individuality and their effects on human health
Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF, Wittemans LBL, Bomba L, Menni C, Zierer J
and 24 more — show all
Rossi N, Sheridan PA, Watkins NA, Mangino M, Hysi PG, Di Angelantonio E, Falchi M, Spector TD, Soranzo N, Michelotti GA, Arlt W, Lotta LA, Denaxas S, Hemingway H, Gamazon ER, Howson JMM, Wood AM, Danesh J, Wareham NJ, Kastenmüller G, Fauman EB, Suhre K, Butterworth AS, Langenberg C
Nature medicine · 2022 · PMID 36357675 · open access

Questions about rs9332217

What is rs9332217?

rs9332217 is a single position in the genome, in or near the CYP2C9 gene. Published research associates it with x-21849 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs9332217 affect how medicines work?

CYP2C9 carries pharmacogenomic findings for Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9332217 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9332217 come from?

GWAS Catalog, Nature medicine 2022, PMID:36357675. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

X-21849 levels (rs9332217). MyGeneLog™. https://www.mygenelog.com/variants/rs9332217

← See all variants