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Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial protein levels (SomaScan ID:25464-1)

CYP2C9 · rs80159642

Where this position leads

Drugs: Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin

rs80159642 Drug: Acenocoumarol and phenprocoumon Acenocoumarol and phenprocoumon Drug Drug: NSAIDs NSAIDs Drug Drug: Phenytoin and fosphenytoin Phenytoin and fosphenytoin Drug Drug: Siponimod Siponimod Drug Drug: Statins Statins Drug Drug: Sulfonylureas Sulfonylureas Drug Drug: Warfarin Warfarin Drug rs80159642 rs80159642 CYP2C9

What the study found

Who was studied 198 Shetland Isles origin ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.726 lower (95% confidence interval 0.57-0.88); p = 2 × 10−9.

Where it sits Chromosome 10, band 10q23.33 — in an intron of CYP2C9.

What each result means

A/A No copy of the version the research linked to Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial protein levels (SomaScan ID:25464-1). This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial protein levels (SomaScan ID:25464-1). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial protein levels (SomaScan ID:25464-1). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs80159642

What is rs80159642?

rs80159642 is a single position in the genome, in or near the CYP2C9 gene. Published research associates it with deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial protein levels (somascan id:25464-1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs80159642 affect how medicines work?

CYP2C9 carries pharmacogenomic findings for Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs80159642 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs80159642 come from?

GWAS Catalog, Communications biology 2025, PMID:40883583. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial protein levels (SomaScan ID:25464-1) (rs80159642). MyGeneLog™. https://www.mygenelog.com/variants/rs80159642

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