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Omega-3 fatty acid levels

CYP2C9 · rs55891451

Where this position leads

Drugs: Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin

rs55891451 Drug: Acenocoumarol and phenprocoumon Acenocoumarol and phenprocoumon Drug Drug: NSAIDs NSAIDs Drug Drug: Phenytoin and fosphenytoin Phenytoin and fosphenytoin Drug Drug: Siponimod Siponimod Drug Drug: Statins Statins Drug Drug: Sulfonylureas Sulfonylureas Drug Drug: Warfarin Warfarin Drug rs55891451 rs55891451 CYP2C9

What the study found

Who was studied 115,006 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0332 lower (95% confidence interval 0.023-0.043); p = 2 × 10−11.

How common The A allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of CYP2C9.

What each result means

A/A Two copies of the version the research linked to Omega-3 fatty acid levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Omega-3 fatty acid levels. That is a smaller link than two copies.
C/C No copy of the version the research linked to Omega-3 fatty acid levels. This is the starting point the study compared everyone against.
Source

Questions about rs55891451

What is rs55891451?

rs55891451 is a single position in the genome, in or near the CYP2C9 gene. Published research associates it with omega-3 fatty acid levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs55891451 affect how medicines work?

CYP2C9 carries pharmacogenomic findings for Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs55891451 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs55891451 come from?

GWAS Catalog, PLoS biology 2022, PMID:35213538. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Omega-3 fatty acid levels (rs55891451). MyGeneLog™. https://www.mygenelog.com/variants/rs55891451

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