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Appendicular lean mass

CYP2C9 · rs28371678

Where this position leads

Drugs: Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin

rs28371678 Drug: Acenocoumarol and phenprocoumon Acenocoumarol and phenprocoumon Drug Drug: NSAIDs NSAIDs Drug Drug: Phenytoin and fosphenytoin Phenytoin and fosphenytoin Drug Drug: Siponimod Siponimod Drug Drug: Statins Statins Drug Drug: Sulfonylureas Sulfonylureas Drug Drug: Warfarin Warfarin Drug rs28371678 rs28371678 CYP2C9

What the study found

Who was studied 181,862 European ancestry elderly individuals.

The effect Each copy of the C allele shifted the measure 0.1 higher (95% confidence interval 0.071-0.129); p = 6 × 10−13.

How common The C allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of CYP2C9.

What each result means

C/C Two copies of the version the research linked to Appendicular lean mass. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Appendicular lean mass. That is a smaller link than two copies.
T/T No copy of the version the research linked to Appendicular lean mass. This is the starting point the study compared everyone against.
Source
Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2
Hernandez Cordero AI, Gonzales NM, Parker CC, Sokolof G, Vandenbergh DJ, Cheng R, Abney M, Sko A, Douglas A, Palmer AA, Gregory JS, Lionikas A
American journal of human genetics · 2019 · PMID 31761296

Questions about rs28371678

What is rs28371678?

rs28371678 is a single position in the genome, in or near the CYP2C9 gene. Published research associates it with appendicular lean mass. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs28371678 affect how medicines work?

CYP2C9 carries pharmacogenomic findings for Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs28371678 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28371678 come from?

GWAS Catalog, American journal of human genetics 2019, PMID:31761296. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Appendicular lean mass (rs28371678). MyGeneLog™. https://www.mygenelog.com/variants/rs28371678

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